Sequence alignment generation using intermediate sequence search for homology modeling
نویسندگان
چکیده
منابع مشابه
Homology-extended sequence alignment
We present a profile-profile multiple alignment strategy that uses database searching to collect homologues for each sequence in a given set, in order to enrich their available evolutionary information for the alignment. For each of the alignment sequences, the putative homologous sequences that score above a pre-defined threshold are incorporated into a position-specific pre-alignment profile....
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Phylogenetic analysis depends crucially on the data underlying the analysis, with issues of data quality being but one aspect of the problem. A second, slightly less appreciated aspect is that of data comparability and specifically the evolutionary homology (= derivation from a common shared ancestry) of the individual characters being examined. The goal of sequence alignment is to establish th...
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Homology-based modeling, or more simply homology modeling, is becoming increasingly important. Models accurate to within 1-2 Å RMS deviation from the actual three-dimensional structure can be produced by homology modeling in favorable cases. With the number of known threedimensional structures projected to grow to more than ten thousand structures by the end of the decade, it will be possible t...
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Finding the best matching database target to a melodic query has been of great interest in the music IR world. The string alignment paradigm works well for this task when comparing a monophonic query to a database of monophonic pieces. However, most tonal music is polyphonic, with multiple concurrent musical lines. Such pieces are not adequately represented as strings. Moreover, users often rep...
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ژورنال
عنوان ژورنال: Computational and Structural Biotechnology Journal
سال: 2020
ISSN: 2001-0370
DOI: 10.1016/j.csbj.2020.07.012